So I'd like to... more consistently write this story like how I do with the Land of the Fallen Fairies (not that that means I have a first draft after eight years but it's fineeeeee)
Here's my bare bones update, on ~scientifically researched lore that will become the backbone of the concept ~
Basically, there's effector caspases - caspase 3 and caspase 7 - that cause apoptosis in cells, and when one cell goes through apoptosis, those same caspases initiate a signaling pathway to neighboring cells so they can go through mitosis and repopulate the emptiness. It's how lizards regrow their tails and how wounds heal and new blood vessels form.Â
The issue is in tumors - if a tumorigenic cell undergoes apoptosis then other tumorigenic cells also proliferate, hence malignant cancer.Â
AND I SHALL TURN THIS INTO A BIOLOGY FANFICTION ABOUT BEING UNSATISFIED WITH A LIFE YOU'RE LUCKY TO HAVE HEHEHEHHEHALFLKDSJFKLSJDFKLJDSKLFJ
And in some way, shape or form I'd like to bring in the concept of the duality of cellular processes. If there isn't metaphors for how the 'power house of the cell' also releases cytochrome c to activate caspase-9 and trigger apoptosis... then I don't know what is.
Also silly silly me thought that capases float around only in the mitochondria? When I don't remember getting that specifically confirmed? There's no reason for them to only float around in the mitochondria when there's lots of capase-3 zymogens floating around in the cytoplasm.
(I'm working up the courage to ask experts about my questions but... courage... it eludes me.)
So.
The main character will be a caspase-3 called Tezra who's been activated not for apoptosis, but rather for regulating the cell cycle. (Caspase-3 cleaves an inhibitor of cyclin dependent kinases) They're one of the 'lucky ones' that gets to live a rather ordinary and quaint little life... deep down they have a sinking feeling of apathy. They know that they're lucky and should live this out to the fullest - inactive zymogens for capase-3 float around in the cytoplasm like the ghostly reminders they are - but there's a bit of... something... something missing.
Enter apoptosis, the promise of complete and total satisfaction (proteins most value completing their purpose and earing the satisfaction it provides them), but also the promise of the end, of nothing more than a single moment. How can Tezra be sure if will be enough?
Insert some Time travel because why not, maybe necrosis - I still have to verify that it's scientifically accurate... because all I got for necrosis is that tissue injury causes it, and a vague recollection that if the caspase systems were bypassed necrosis would occur.. but I'm not sure! ALSO BETRAYAL! AND I STILL HAVE TO DEVELOP A LOT OF THIS
But Tezra is a sarcastic little silly so I can definitely put all my future dreams into this story